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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1974 1
1976 1
1977 4
1978 1
1979 2
1980 1
1981 5
1982 5
1983 3
1984 3
1985 9
1986 5
1987 10
1988 13
1989 9
1990 7
1991 15
1992 16
1993 13
1994 10
1995 21
1996 21
1997 17
1998 18
1999 18
2000 23
2001 26
2002 27
2003 32
2004 29
2005 47
2006 49
2007 60
2008 51
2009 64
2010 68
2011 67
2012 82
2013 80
2014 86
2015 63
2016 101
2017 109
2018 117
2019 108
2020 105
2021 105
2022 134
2023 125
2024 50

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1,808 results

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Page 1
Two-stage designs in bioequivalence trials.
Schütz H. Schütz H. Eur J Clin Pharmacol. 2015 Mar;71(3):271-81. doi: 10.1007/s00228-015-1806-2. Epub 2015 Jan 22. Eur J Clin Pharmacol. 2015. PMID: 25604509 Review.
RESULTS: Add-on designs, group sequential designs and adaptive two-stage sequential designs are currently accepted to demonstrate bioequivalence in various regulations. ...Two-stage designs are both ethical and economical alternatives to fixed s …
RESULTS: Add-on designs, group sequential designs and adaptive two-stage sequential designs are currently accepted to demonstr …
Implementing two-stage consent pathway in neonatal trials.
Mitchell E, Oddie SJ, Dorling J, Gale C, Johnson MJ, McGuire W, Ojha S. Mitchell E, et al. Arch Dis Child Fetal Neonatal Ed. 2023 Jan;108(1):79-82. doi: 10.1136/archdischild-2021-322960. Epub 2021 Dec 23. Arch Dis Child Fetal Neonatal Ed. 2023. PMID: 34949637 Free PMC article.
Perinatal trials sometimes require rapid recruitment processes to facilitate inclusion of participants when interventions are time-critical. A two-stage consent pathway has been used in some trials and is supported by national guidance. ...
Perinatal trials sometimes require rapid recruitment processes to facilitate inclusion of participants when interventions are time-critical. …
A randomized comparison of two-stage versus traditional one-stage consent for a low-stakes randomized trial.
Vickers AJ, Vertosick EA, Austria M, Gaffney CD, Carlsson SV, Kim SY, Ehdaie B. Vickers AJ, et al. Clin Trials. 2023 Dec;20(6):642-648. doi: 10.1177/17407745231185058. Epub 2023 Jul 4. Clin Trials. 2023. PMID: 37403311 Free PMC article. Clinical Trial.
In a post hoc analysis, consent-related anxiety was lower among two-stage control patients, likely because scores were measured close to the time of biopsy in the two-stage patients receiving the experimental intervention. ...Further research is …
In a post hoc analysis, consent-related anxiety was lower among two-stage control patients, likely because scores were …
The Enigmatic Protein Kinase C-eta.
Basu A. Basu A. Cancers (Basel). 2019 Feb 13;11(2):214. doi: 10.3390/cancers11020214. Cancers (Basel). 2019. PMID: 30781807 Free PMC article. Review.
Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCeta) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. ...However, mice lacking PKCeta …
Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (P …
Cytokinin signaling regulates two-stage inflorescence arrest in Arabidopsis.
Walker CH, Ware A, Šimura J, Ljung K, Wilson Z, Bennett T. Walker CH, et al. Plant Physiol. 2023 Jan 2;191(1):479-495. doi: 10.1093/plphys/kiac514. Plant Physiol. 2023. PMID: 36331332 Free PMC article.
To maximize reproductive success, flowering plants must correctly time entry and exit from the reproductive phase. While much is known about mechanisms that regulate initiation of flowering, end-of-flowering remains largely uncharacterized. ...We showed that global inflore …
To maximize reproductive success, flowering plants must correctly time entry and exit from the reproductive phase. While much is known about …
Comparative effectiveness of one versus two-stage sacral neurostimulation device placement.
Patel DN, Zhao HH, Houman J, Ackerman AL, Eilber KS, Anger JT. Patel DN, et al. Neurourol Urodyn. 2019 Feb;38(2):734-739. doi: 10.1002/nau.23908. Epub 2019 Jan 8. Neurourol Urodyn. 2019. PMID: 30620133
OBJECTIVE: Sacral neurostimulation (SNS) is an effective third-line treatment for overactive bladder. We sought to compare the cost of standard two-stage SNS device placement to that of a combined one-stage placement using a Markov chain model. ...In a two- …
OBJECTIVE: Sacral neurostimulation (SNS) is an effective third-line treatment for overactive bladder. We sought to compare the cost of stand …
Patient accrual and understanding of informed consent in a two-stage consent design.
Vickers AJ, Vertosick EA, Carlsson SV, Ehdaie B, Kim SYH. Vickers AJ, et al. Clin Trials. 2021 Jun;18(3):377-382. doi: 10.1177/1740774520988500. Epub 2021 Feb 2. Clin Trials. 2021. PMID: 33530713 Free PMC article.
BACKGROUND: We previously introduced the concept of "two-stage" (or "just-in-time") informed consent for randomized trials with usual care control. ...CONCLUSION: We found promising data that two-stage consent facilitated accrual without comprom …
BACKGROUND: We previously introduced the concept of "two-stage" (or "just-in-time") informed consent for randomized trials wit …
Assessing health research grant applications: A retrospective comparative review of a one-stage versus a two-stage application assessment process.
Morgan B, Yu LM, Solomon T, Ziebland S. Morgan B, et al. PLoS One. 2020 Mar 12;15(3):e0230118. doi: 10.1371/journal.pone.0230118. eCollection 2020. PLoS One. 2020. PMID: 32163468 Free PMC article.
RESULTS: There was a mean number of 114 applications per funding round for the one-stage process and 136 for the two-stage process. The one-stage process took a mean of 274 days and the two-stage process 348 days to complete, although those who were no …
RESULTS: There was a mean number of 114 applications per funding round for the one-stage process and 136 for the two-stage pro …
Environmental Regulation of PndbA600, an Auto-Inducible Promoter for Two-Stage Industrial Biotechnology in Cyanobacteria.
Madsen MA, Hamilton G, Herzyk P, Amtmann A. Madsen MA, et al. Front Bioeng Biotechnol. 2021 Jan 19;8:619055. doi: 10.3389/fbioe.2020.619055. eCollection 2020. Front Bioeng Biotechnol. 2021. PMID: 33542914 Free PMC article.
In the present study, we identified and characterised a growth phase-specific promoter, which can serve as an auto-inducible switch to regulate two-stage bioprocesses in cyanobacteria. First, growth phase-specific genes were identified from a new RNAseq datas …
In the present study, we identified and characterised a growth phase-specific promoter, which can serve as an auto-inducible switch to re …
1,808 results